Metabolic and immunohistochemical assessment of endocrine pancreatic function after orthotopic multivisceral transplantation.

IT is well known that pancreatic allografts normalize hyperglycemia a few hours after reperfusion. Endocrine function has been intensively studied in pancreas allografts from a biochemical point of view. Outstanding among functional studies is intravenous (IV) glucagon test, which has rarely been used in pancreas transplantation. However, there is little information on early histochemical aspects of pancreas transplantation and endocrine function has not been properly studied in multivisceral transplantation with the pancreas allograft draining into the portal vein of the liver graft. We studied the endocrine function of the orthotopically transplanted pancreas after multiorgan procurement in a multivisceral transplantation model in a previously reported model.